8 Spa Hotels and Resorts for Your Wellness Vacation

Fort Myers is more than a coastal region; it's a true rejuvenation destination. If you’re looking for a beachfront escape, a restorative spa getaway or a family-friendly vacation, these islands, beaches and neighborhoods have healing qualities that put your well-being front and center. For every style of treatment from overall relaxation and restoration to prenatal comfort and wedding preparation, discover eight Fort Myers hotels and resorts with exceptional spas right on the property.

The Spa at Sanibel Harbor

Unwind at one of the region's largest full-service spas and wellness centers — 40,000 square feet to be exact. Inside Marriott Sanibel Harbour Resort & Spa, you’ll immediately be at ease as you take in the coastal tones, soft lighting and calming aromas of botanicals. Skilled practitioners have perfected their techniques with offerings like the Sanibel Relaxation — a soothing massage with a light to medium touch. For an extra-special treat, try the signature Slice of Sunshine (S.O.S.) Aromatherapy, which infuses aromas of sweet orange and honey into your massage. A full hydrotherapy circuit includes a pool, steam rooms, saunas, and whirlpools for a fully restorative retreat that feels indulgent and deeply restful. Finish off a relaxing day of coastal-inspired cuisine and drinks accompanied by captivating views of Sanibel and Captiva islands.

Stillwater Spa & Salon

Earning a spot on Travel + Leisure's 2025 World's Best Awards, Hyatt Regency Coconut Point Resort & Spa is a tropical paradise where family fun is well balanced by ultimate relaxation. At Stillwater Spa & Salon, gentle natural tones, cozy lighting and treatment rooms are inspired by nature — creating a calming haven for solo or couples treatments. Nourish your skin with the spa’s popular HydraFacial that fully exfoliates and refreshes your pores with a rich, hydrating super serum. Other treatments incorporate natural ingredients such as golden honey, vitamin C and CBD, while expert masseuses specialize in areas like reflexology and sports recovery.

Not to be left out, kids and teens get to enjoy the resort's lazy river, waterslides and multiple pools. For true family bonding, take a 15-minute shuttle ride to the resort's private island, where you can spot wildlife such as dolphins, birds and reptiles or find solace in the outdoor lounges.

The Spa at ‘Tween Waters

Relax and reconnect with nature at ‘Tween Waters Inn & Marina, tucked snugly between the Gulf of Mexico and Pine Island Sound. Retreat to The Spa at ‘Tween Waters for a whole suite of services in an intimate setting. Choose from options such as a warm stone massage to a more intensive deep-tissue massage, or turn back the clock with an antiaging facial and glycolic mask and walk out feeling fully refreshed.

Continue your day outside in the soft salt air as you stroll sugar-sand beaches or paddle peacefully in a kayak or on a stand-up paddleboard. When you’re not floating in the pool, sipping on cocktails or relishing the bright, mouthwatering cuisine at the historic Old Captiva House, dive into adventure — the resort’s marina offers boat rentals, shelling and fishing trips, while complimentary bikes make exploring the island’s beauty effortless.

Kay Casperson Lifestyle Spa

On the edge of the Gulf, discover this gem inside Sundial Beach Resort & Spa. Rejuvenation is guaranteed with a 50- or 80-minute massage, while couples can enjoy all the benefits of side-by-side relaxation. Stop in for a 25-minute glow-and-go facial for a quick refresh, or stick around for a longer treatment or nano needling facial.

After the spa, set out on a guided tour on the seashell-covered beach with a marine expert from the Bailey-Matthews National Shell Museum & Aquarium, lounge under the swaying palm trees, or bike along Sanibel Island’s extensive network of bike paths. With condo-style accommodations that feel like a home away from home, wellness flows from the sea to the shore.

Esterra Spa & Salon

Arriving in canal-lined Cape Coral immediately puts you into vacation mode, as The Westin Cape Coral Resort at Marina Village overlooks a boat-lined marina with views extending over lush mangroves and preserves. Coastal bliss follows you into Esterra Spa & Salon where you can try unique offerings like a detoxifying bamboo massage paired with Pure Fiji coconut milk and honey oil, or a deep-tissue treatment using cupping techniques. Island-inspired wraps and scrubs restore your skin to better health.

Soak up Florida’s sun or lie under the stars by the pool, roam The Promenade Shop or find inner peace with Yoga On The Lawn. You may even catch sight of manatees floating through the water and dolphins playing in the distance from your spectacular balcony view or while on a scenic boat ride.

St. Somewhere Spa

Walk into paradise at Margaritaville Beach Resort. The vibrant atmosphere extends to the St. Somewhere Spa, where a fresh, modern beach aesthetic, crisp whites and subtle ocean accents create a serene escape from the resort’s lively energy. Escape to a different kind of island vibe with a black sand body scrub, or tailor your restorative facial with the essence of piña colada, mango margarita or strawberry daiquiri. Lavender oil transforms a massage into a sleep aid, and an aromatherapy-infused couples massage will melt your tensions away.

When you’re not at the spa, indulge in all the fun of this coastal oasis, from water sports to legendary views at the Sunset Terrace. Your Gulf getaway isn’t complete without a visit to Fins Up! Beach Club, the resort’s vibrant social hub for sunset ceremonies, live entertainment and refreshing tropical cocktails.

The Spa at Shangri-La Springs

Set in an area renowned for its restorative springs, Shangri-La Springs has a range of activities and events to allow your mind and body to drift into peace and calm. Feel renewed at The Spa, where they use organic ingredients to melt away stress and worries. Therapeutic treatments include a light-touch Zen massage and organic aromatherapy using customized essential oils. Healing crystals can reduce the appearance of lines, while a jade roller can reduce inflammation for a refreshed outward glow.

Your well-being journey doesn’t end at the spa. Take an outdoor yoga or meditation class, and let the sounds of the Shangri-La Springs Mermaid Water Fountain lull you into tranquility on the botanical grounds. The resort’s natural mineral spring flows throughout the property, creating a soothing backdrop that extends the sense of renewal and connection to the environment. Explore the Organic Garden, where fresh fruits and vegetables are harvested to be prepared and served at Harvest & Wisdom.

The Gasparilla Inn Spa

The Gasparilla Inn’s Old Florida elegance meets modern-day serenity where you can embrace the easy rhythm of island life. Try a Touch of Gasparilla, the ultimate combination of both Swedish and deep-tissue massages, enhanced by hot stone and reflexology treatments, culminating in a deeply relaxing oil scalp massage. True to the resort’s commitment to leisure activities like golf, croquet and swimming, a Boca rejuvenation massage targets tired muscles, while mini-treatments will get you back outside in no time. Exfoliating scrubs incorporate ingredients like guava and lemongrass for maximum benefits.

Once you’re out and about, there are endless ways to unwind. Tee off on the scenic golf course, snorkel through crystal blue waters or play a round of croquet on the same lawns that have hosted international tournaments over the years. Spend some time along the shoreline basking in the sun, lounge in the shade under palm trees or cool off with a refreshing swim.

Ready for a reset? Discover more of Fort Myers’ relaxing vacation spots and ways to wellness on your next vacation.